The Pharmacology (PC) unit is the central body in CPR responsible for establishing and optimizing assays to evaluate candidate antibodies. The PC unit places strong emphasis on designing assays which are not only robust, highly sensitive, but also physiologically relevant, by taking into account the natural biology of the target molecule. In addition to assay development, the PC unit is also tasked with screening the panel of antibodies to identify hits with superior characteristics. To do this, the PC unit employs a wide range of high throughput assay systems to assess the function of antibodies generated by the other research units within CPR. Hence, the PC team strongly values broad-based expertise in multiple areas such as pharmacology, molecular biology, biochemistry, physiology, and pathology.
The Translational Pharmacology (TR) unit is responsible for immunization, PK/PD analysis and biomarker exploration and supports pharmacological studies.