Research Units

Research Units

Lead Optimization

The Lead Optimization (LO) unit is the chief division in steering lead antibody drugs to meet the target antibody profile. Through the execution of comprehensive mutagenesis and high throughput screening, LO unit is able to identify monoclonal antibodies with vastly improved binding characteristics, physicochemical and pharmacokinetic properties, as well as minimal immunogenicity. This process of antibody engineering encompasses molecular cloning, small-scale protein expression in mammalian system and multi-dimensional analysis. The LO unit works closely with other research units in CPR to discover and optimize suitable drug candidates.