Research Assistant
Research Division
Your role is to conduct experiments assigned by the Senior Scientist. You must possess the relevant scientific knowledge required, strong communication skills to work with your team, and a pro-active mindset for continuous improvement.
Job Description
- Tool generation – expression vector construction, expression, stable cell lines development
- Antibody generation – B cell cloning, antibody library
- Antibody screening – ELISA, FACS, cell-based functional assay etc.
- Lead optimization – expression vector construction, expression
- Protein Analysis – Biacore analysis, column chromatography analysis (IE, SE, RP etc.), SDS-PAGE, other physiochemical analysis
- Pharmacokinetics – sample measurement in in vitro and in vivo samples and PK simulation
- Protein purification – column chromatography, SDS-PAGE, Western Blotting
- Pharmacology (Oncology) – Development and performance of functional cell-based and cell-free assay, preferably in immunology and/or oncology
Requirements
- Degree in Biomedical Science/Biotechnology/Molecular Biotechnology or a related field with at least 1-2 years of related working experience.
- Familiar with basic laboratory procedures. Experience in Molecular Biology, Protein Chemistry, Protein Purification techniques, Cell culture, Flow Cytometry, Confocal Microscopy and other relevant skills will be an added advantage.
- Fresh graduates are welcome to apply
Overview
We are seeking a motivated Research Assistant to join our Translational Pharmacology Unit. In this role, you will support the unit through in vivo and in vitro pharmacology studies, including the establishment and characterisation of in vivo pharmacology models, evaluation of drug efficacy and biological activity, assessment of mechanism of action, and support of PK/PD and biomarker studies for therapeutic candidates.
You will work according to established SOPs, ensure high standards of data quality and integrity, and participate in routine laboratory maintenance and animal husbandry duties. You will also collaborate closely with team members and colleagues from other units.
You communicate clearly, collaborate well in multidisciplinary settings, and take ownership of assigned tasks. You are eager to learn, open to feedback, and committed to continuously improving your technical skills. You work with care and attention to detail, stay organized, and manage multiple tasks in a fast-paced environment.
Key Responsibilities:
- Support the evaluation of drug efficacy, pharmacological activity and biological activity.
- Establish, maintain and characterise in vivo pharmacology models to support drug discovery and development projects.
- Perform Pharmacokinetic (PK), Pharmacodynamic (PD), and biomarker studies to support translational research.
- Follow experimental protocols carefully and ensure all procedures are performed consistently, safely, and in compliance with SOPs.
- Carry out animal immunization procedures and monitor study outcomes according to established protocols.
- Perform animal husbandry duties, including animal care, health monitoring, record maintenance and related activities in accordance with established protocols.
Requirements:
- Degree in Biomedical Science/Biochemistry/Chemical Biology/Biotechnology/Molecular Biotechnology or related field.
- 0-2 years of relevant research experience. Fresh graduates with a keen interest in in vivo pharmacology are welcome to apply.
- Familiarity with basic laboratory procedures, including sample preparation, pipetting, reagent preparation, and data recording.
- Hands-on experience with one or more of the following techniques is preferred:
– Molecular Biology techniques
– Cell Culture
– Flow Cytometry
– Quantitative Polymerase Chain Reaction (qPCR) - Candidates with experience in handling animals such as mice, rats and/or rabbits are highly encouraged to apply.