CAREERS

Overview

CPR is seeking a motivated Senior Scientist with demonstrated expertise in protein engineering and a strong passion for medical science. This position offers the opportunity to contribute to the discovery and development of innovative drugs designed to address unmet medical needs.

Key responsibilities

• Optimize Lead Candidates: Drive humanization, affinity optimization, and the optimization of physicochemical properties to significantly improve the pharmacokinetics (PK), safety and efficacy of therapeutic antibodies.
• Engineer Antibody Formats: Design, construct, and evaluate diverse antibody formats including bispecifics antibodies, antibody fragments, antibody-drug conjugates (ADCs), and fusion proteins, to achieve optimal structural stability, developability, and precise therapeutic functions.
• Pioneer New Antibody Technologies: Lead the research and development of next-generation antibody platforms, novel discovery methodologies, and proprietary engineering technologies to expand the therapeutic pipeline and address complex disease targets.
• Drive Cross-Functional Collaboration: Partner closely with diverse scientific departments such as target biology, pharmacology, and manufacturing to advance engineered therapeutics from discovery through development.

Required Qualifications

• PhD in Biomedical Science, Biochemistry, Chemical Biology, Biotechnology, Information Science, or a related discipline.
• Demonstrated technical expertise in areas such as molecular biology, cell biology, protein chemistry, or protein engineering, evidenced by research projects, presentations, patents, and/or peer-reviewed publications.

• Demonstrated strong expertise in at least one of the following areas:

• • Protein and/or antibody engineering, including rational or random mutagenesis approaches.
  • Structural and molecular biology for protein structure and function investigation.
  • Structural modelling and/or machine learning.
  • Protein biochemistry, including protein expression, purification, and characterisation.
• Excellent organisational skills with the ability to manage and interpret large datasets.
• Strong communication and collaboration skills, with the ability to work effectively in cross-functional and multidisciplinary teams.
• Good command of spoken and written English.
• Self-motivated team player with the capability of managing multiple priorities in a dynamic research environment.

Preferred Qualifications

• Prior work experience in antibody drug discovery.
• Knowledge of high-throughput systems, automation, and/or general scripting languages.
• Knowledge of cell biology, biophysics or immunology.

CPR is seeking a highly motivated and scientifically rigorous Pharmacologist who is passionate about generating innovative ideas and translating disease biology into impactful therapeutics for patients with unmet medical needs.

You bring strong expertise in both in vitro and in vivo pharmacology to drive target validation and antibody-based drug discovery. Reporting to the Research Manager, you will lead defined studies and workstreams and participate in cross-functional discussions to advance projects across the discovery pipeline.

Key Responsibilities:

• Design, plan, and oversee in vitro and/or in vivo pharmacology studies to assess efficacy, establish mechanism of action.
• Develop and optimize screening strategies and functional assays for antibody programs.
• Analyze, interpret, and clearly communicate data; deliver reports and presentations to inform project decisions and go/no-go milestones.
• Mentor junior scientists/research associates; foster scientific rigor and a collaborative culture.
• Propose innovative hypotheses and new project concepts
• Prepare scientific publications and patent applications in collaboration with cross-functional teams

Required Qualifications:

• Ph.D. in Pharmacology, Life Sciences, or a related scientific field with 0 – 3+ years of relevant industry or research experience, preferably in a pharmaceutical or biomedical research environment
• Strong foundation in molecular and cell biology, demonstrated through research outputs (e.g., presentations or peer-reviewed publications)
• Hands-on expertise designing, planning, and analyzing in vitro and/or in vivo pharmacology studies
• Strong critical thinking and problem-solving skills with the ability to interpret complex datasets and generate actionable insights.
• Effective communication and collaboration skills, with the ability to contribute to project outcomes in cross-functional teams

Preferred Qualifications:

• Post‑PhD industry or postdoctoral experience in drug discovery with demonstrated contributions to target validation, screening strategy, or lead identification.
• Experience independently driving in vitro and/or in vivo studies; track record of delivering decision‑enabling data (e.g., internal milestones, publications, or patents).
• Experience in translational pharmacology, including linking mechanistic findings to disease-relevant models
• Experience working in cross-functional drug discovery teams (e.g., biology, antibody engineering, DMPK)

We regret that only short-listed candidates will be notified.